News article: "‘Miracle molecules’ discovered? Scientists find compound that reverses aging, develop ‘longevity drug’ " located at https://studyfinds.org/miracle-drug-reverse-aging-process/ .See also https://www.eurekalert.org/news-releases/960488 . [That latter article is called "New molecule developed at Hebrew U. may prevent age-related diseases and increase life expectancy and wellness: With a constant renewal of cell vitality in diseased tissues, this new drug will hopefully lead to the treatment or prevention of diseases, such as Alzheimer’s and Parkinson’s".] Those articles were based upon an article in the science journal called Autophagy. The abstract of the science journal article is located at https://www.tandfonline.com/doi/abs/10.1080/15548627.2022.2078069?journalCode=kaup20 . The abstract of that article says the following.
"Impaired mitophagy is a primary pathogenic event underlying diverse aging-associated diseases such as Alzheimer and Parkinson diseases and sarcopenia. Therefore, augmentation of mitophagy, the process by which defective mitochondria are removed, then replaced by new ones, is an emerging strategy for preventing the evolvement of multiple morbidities in the elderly population. Based on the scaffold of spermidine (Spd), a known mitophagy-promoting agent, we designed and tested a family of structurally related compounds. A prototypic member, 1,8-diaminooctane (VL-004), exceeds Spd in its ability to induce mitophagy and protect against oxidative stress. VL-004 activity is mediated by canonical aging genes and promotes lifespan and healthspan in C. elegans. Moreover, it enhances mitophagy and protects against oxidative injury in rodent and human cells. Initial structural characterization suggests simple rules for the design of compounds with improved bioactivity, opening the way for a new generation of agents with a potential to promote healthy aging."
Notice that the article mentions "spermidine". That substance was first isolated from semen and it was found in human sperm, hence its name. Many foods are high in spermidine, including dry soy bean, chicken liver, green peas, corn, shell fish, and blue cheese. Spermidine is commercially available as supplemen. https://www.lifespan.io/topic/spermidine/ says the following.
"It is worth noting that much of the Mediterranean diet contains spermidine rich foods. This may at least explain the phenomena of the “blue zones” and why people there often live longer than elsewhere.
If you struggle to get enough in your diet you can also get it as a spermidine supplement. The synthetic spermidine used in supplements is identical to the naturally occurring molecule.
... It is most well known for its ability to boost autophagy, a cellular recycling routine that can help cells remove waste and unwanted components, which is also the most likely reason it may influence aging."
https://novoslabs.com/best-anti-aging-supplements-that-harvard-scientist-david-sinclair-takes/ says that spermidine is one of the supplements which David Sinclairtakes.